Resolution of H ypoprothrombinemia‐ L upus A nticoagulant S yndrome ( HLAS ) after multidrug therapy with rituximab: a case report and review of the literature

Summary Hypoprothrombinemia associated with a lupus anticoagulant ( LA ) was first reported in the literature over 50 years ago. The hypoprothrombinemia‐lupus anticoagulant syndrome ( HLAS ) is a rare bleeding diathesis that has been associated with LA s in adult and paediatric patients with systemic lupus erythematosus ( SLE ) and with transient LA s due to other causes. There are no standard recommendations for treating haemorrhage associated with this syndrome. Herein, we report a patient with SLE and HLAS who achieved a durable remission following treatment with intravenous immune globulin ( IVIG ), prednisone and rituximab.