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Resolution of H ypoprothrombinemia‐ L upus A nticoagulant S yndrome ( HLAS ) after multidrug therapy with rituximab: a case report and review of the literature
Author(s) -
Paschal R. D.,
Neff A. T.
Publication year - 2013
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.12027
Subject(s) - medicine
Summary Hypoprothrombinemia associated with a lupus anticoagulant ( LA ) was first reported in the literature over 50 years ago. The hypoprothrombinemia‐lupus anticoagulant syndrome ( HLAS ) is a rare bleeding diathesis that has been associated with LA s in adult and paediatric patients with systemic lupus erythematosus ( SLE ) and with transient LA s due to other causes. There are no standard recommendations for treating haemorrhage associated with this syndrome. Herein, we report a patient with SLE and HLAS who achieved a durable remission following treatment with intravenous immune globulin ( IVIG ), prednisone and rituximab.