Premium
Immunoglobulin superfamily beat‐Ib mediates intestinal regeneration induced by reactive oxygen species in Drosophila
Author(s) -
Nagai Hiroki,
Kurata Shoichiro,
Yano Tamaki
Publication year - 2020
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12762
Subject(s) - biology , microbiology and biotechnology , enterocyte , reactive oxygen species , stem cell , regeneration (biology) , immunology , small intestine , biochemistry
Reactive oxygen species (ROS) often injure intestinal epithelia that cause loss of damaged cells, which is mainly repaired by proliferation of intestinal stem cells (ISCs). To maintain the homeostatic state, coordination of sensing of the ROS injury and the subsequent epithelial cell loss with the replenishment by cell renewal is crucial. However, little is known about how gut epithelial cells initiate regenerative responses against ROS to maintain the tissue integrity. Here, we carried out a genome‐wide screen, by which we identify immunoglobulin superfamily beaten path Ib ( beat‐Ib ) as an essential gene for provoking ISC proliferation against ROS in Drosophila intestine. Interestingly, the beat‐Ib function is required in differentiated enterocytes, the main targeted cells by ROS in the intestinal tract, but is dispensable in the stem cells. Moreover, beat‐Ib is not involved in enterocyte apoptosis at ROS injury. These findings indicate the essential role of beat‐Ib in Drosophila midgut enterocytes for initiating the non‐cell‐autonomous induction of ISC division in response to environmental ROS stresses.