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Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass
Author(s) -
Yang Bo,
Kumoto Takahiro,
Arima Takeshi,
Nakamura Minako,
Sanada Yohei,
Kumrungsee Thanutchaporn,
Sotomaru Yusuke,
Shimada Masayuki,
Yanaka Noriyuki
Publication year - 2018
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12558
Subject(s) - amphiregulin , adipose tissue , white adipose tissue , biology , endocrinology , medicine , adipose tissue macrophages , adipokine , prdm16 , receptor , leptin , growth factor , obesity , biochemistry
To determine adipocytokines that play a regulatory role during obesity development, we explored the genes that encode growth factors and investigated the physiological functions for adipose tissue development. Here, we isolated amphiregulin ( Areg ) gene whose expression was significantly up‐regulated in obese adipose tissues. Areg mRNA level was positively correlated with macrophage marker gene expression in adipose tissues in vivo. Unexpectedly, Areg transgenic mice showed less adipose tissue mass with increased mRNA expression levels of Tnf‐ α and peroxisome proliferator‐activated receptor γ coactivator 1 α ( Pgc‐1 α) and delayed white adipose tissue development during the convalescent stage in a dextran sodium sulfate‐induced colitis model. This study showed that Areg mRNA expression was significantly up‐regulated in obese adipose tissues and over‐expression of Areg in white adipose tissue caused less adipose tissue mass.