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Two zinc finger proteins from Mycobacterium smegmatis : DNA binding and activation of transcription
Author(s) -
Ghosh Subho,
Chatterji Dipankar
Publication year - 2017
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12507
Subject(s) - zinc finger , ring finger domain , lim domain , biology , phd finger , mycobacterium smegmatis , sp1 transcription factor , zinc finger nuclease , dna binding protein , protein–dna interaction , transcription (linguistics) , dna binding domain , dna , transcription factor , ring finger , microbiology and biotechnology , biochemistry , gene , promoter , gene expression , mycobacterium tuberculosis , medicine , tuberculosis , linguistics , philosophy , pathology
Single zinc finger domain containing proteins are very few in number. Of numerous zinc finger proteins in eukaryotes, only three of them like GAGA , Superman and DNA binding by one finger (Dof) have single zinc finger domain. Although few zinc finger proteins have been described in eubacteria, no protein with single C4 zinc finger has been described in details in anyone of them. In this article, we are describing two novel C‐terminal C4 zinc finger proteins—Msmeg_0118 and Msmeg_3613 from Mycobacterium smegmatis . We have named these proteins as Mszfp1 (Mycobacterial Single Zinc Finger Protein 1) and Mszfp2 (Mycobacterial Single Zinc Finger Protein 2). Both the proteins are expressed constitutively, can bind to DNA and regulate transcription. It appears that Mszfp1 and Mszfp2 may activate transcription by interacting with RNA polymerase.