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Hippo vs. Crab: tissue‐specific functions of the mammalian Hippo pathway
Author(s) -
Nishio Miki,
Maehama Tomohiko,
Goto Hiroki,
Nakatani Keisuke,
Kato Wakako,
Omori Hirofumi,
Miyachi Yosuke,
Togashi Hideru,
Shimono Yohei,
Suzuki Akira
Publication year - 2017
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12461
Subject(s) - hippo signaling pathway , biology , microbiology and biotechnology , hyperactivation , transcription factor , carcinogenesis , suppressor , yap1 , signal transduction , cancer , genetics , gene
The Hippo signaling pathway is a vital suppressor of tumorigenesis that is often inactivated in human cancers. In normal cells, the Hippo pathway is triggered by external forces such as cell crowding, or changes to the extracellular matrix or cell polarity. Once activated, Hippo signaling down‐regulates transcription supported by the paralogous cofactors YAP 1 and TAZ . The Hippo pathway's functions in normal and cancer biology have been dissected by studies of mutant mice with null or conditional tissue‐specific mutations of Hippo signaling elements. In this review, we attempt to systematically summarize results that have been gleaned from detailed in vivo characterizations of these mutants. Our goal is to describe the physiological roles of Hippo signaling in several normal organ systems, as well as to emphasize how disruption of the Hippo pathway, and particularly hyperactivation of YAP 1/ TAZ , can be oncogenic.