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Distribution of human single‐nucleotide polymorphisms is approximated by the power law and represents a fractal structure
Author(s) -
Gouda Norio,
Shiwa Yuh,
Akashi Motohiro,
Yoshikawa Hirofumi,
Kasahara Ken,
Furusawa Mitsuru
Publication year - 2016
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12344
Subject(s) - single nucleotide polymorphism , biology , fractal , power law , genetics , distribution (mathematics) , statistical physics , law , computational biology , physics , mathematics , gene , statistics , genotype , mathematical analysis , political science
Single‐nucleotide polymorphisms ( SNP s) are one of the main causes of evolution. The distribution of human SNP s, which were examined in detail genomewide, was analyzed. Three discrete databases of human SNP s were used for this analysis, and similar results were obtained from these databases. It was found that the distribution of the distance between SNP s was approximated by the power law, and the shape of the regions including SNP s had the so‐called fractal structure. Although the reason why the distribution of SNP s obeys such a certain law of physics is unclear, a speculation was attempted in connection with the three‐dimensional structure of human chromatin which has a fractal structure.