Premium
Issue Information
Publication year - 2016
Publication title -
genes to cells
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12291
Subject(s) - biology , quantitative trait locus , single nucleotide polymorphism , genetics , locus (genetics) , snp , breed , gene , genealogy , genotype , history
Front cover: Among phenotypes, quantitative traits are usually caused by many chromosomal loci (quantitative trait locus, QOL) in a complex manner, and researches using dogs have been fruitful. A number of dog breeds have been produced by human beings. The morphological character is highly variable among breeds, but uniformed within the same breed. Genome‐wide association studies that coupled craniometric data obtained from various dog breeds have been conducted, and QTLs in which SNPs that might affect the skull shape existed concentratively were identified. One of the QTLs was mapped near BMP3 gene on Ch. 32, and it was shown that most breeds with shortened head had a common missense mutation in BMP3 . Data on the background: Figure 3 of Schoenebeck et al . (2012) PLoS Genet. 8, e1002849 (DOI: 10.1371/journal.pgen.1002849 ). Upper panel: SNP distribution around BMP3 locus among various dog breeds. Lower panel: Plots of important SNPs (conserved, exonic, etc.) extracted from the upper panel. Designed by TRAIS Co., Ltd. (Kobe, Japan).