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S u(fu) switches R dx functions to fine‐tune hedgehog signaling in the D rosophila wing disk
Author(s) -
Seong KiHyeon,
Ishii Shunsuke
Publication year - 2013
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/gtc.12018
Subject(s) - hedgehog , nucleus , hedgehog signaling pathway , signal transduction , transcription factor , biology , microbiology and biotechnology , biophysics , materials science , biochemistry , gene
Hedgehog ( H h) signaling plays a central role in pattern formation by regulating transcription factor Cubitus interruptus ( C i). Previously, R oadkill ( R dx, also called HIB ) was shown to inhibit C i activity by two distinct mechanisms, depending on the H h signal strength (Seong et al . 2010, PLoS One 5, e15365). In the anterior region abutting the anterior/posterior ( A / P ) boundary of the wing disk, where cells receive a strong H h signal, R dx blocks the nuclear entry of C i‐155. In contrast, in the region farther from the A / P boundary, where cells receive moderate levels of H h, R dx induces C i‐155 degradation in the nucleus. Here, we report that S uppressor of fused, S u(fu), causes the R dx switch between mechanisms. A strong H h signal induces rdx expression and suppresses su(fu) expression, whereas moderate levels of H h induce moderate levels of rdx expression and high levels of su(fu ) expression. R dx blocks entry of C i‐155 into the nucleus in the absence of S u(fu) and R dx induces the degradation of C i‐155 in the nucleus in the presence of a threshold level of S u(fu). Thus, the S u(fu)‐induced switch between the dual actions of R dx in response to the H h signal strength plays a role in fine‐tuning H h signaling.