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Management guideline for W erner syndrome 2020. 6. Skin ulcers associated with W erner syndrome: Prevention and non‐surgical and surgical treatment
Author(s) -
Kubota Yoshitaka,
Takemoto Minoru,
Taniguchi Toshibumi,
Motegi Seiichiro,
Taniguchi Akira,
Nakagami Hironori,
Maezawa Yoshiro,
Koshizaka Masaya,
Kato Hisaya,
Mori Seijiro,
Tsukamoto Kazuhisa,
Kuzuya Masafumi,
Yokote Koutaro
Publication year - 2021
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/ggi.14096
Subject(s) - medicine , guideline , werner syndrome , metabolic syndrome , pain syndrome , dermatology , surgery , pathology , obesity , helicase , rna , biochemistry , chemistry , gene
Aim To provide guidelines on the diagnosis, treatment, and prevention of skin ulcers in Werner syndrome. Methods This article was based on literature from 1996, when WRN was identified as a gene responsible for Werner syndrome, and we evaluated several authentic clinical cases of genetically diagnosed patients. There were 63 patients with Werner syndrome in the Japanese reports retrieved from Medical Online between January 1996 and December 2017. There were 56 patients with Werner syndrome in English reports written by Japanese authors and retrieved from PubMed during the same period. Results Records on skin ulcers were found in 27 (43%) out of 63 patients and 22 (40%) out of 56 patients from the Japanese and English reports, respectively. The reported ulcers were often located at the distal one‐third of the lower legs. There were 8 patients with callosities in the foot in the Japanese reports and 9 patients in the English reports. A skin ulcer in Werner syndrome is generally intractable. Weight‐bearing ulcers or callosity should be critically assessed in surgical procedures because they have effects on patient pain and gait. By adopting a recently advanced technique to facilitate wound healing, the cases of ulcers that were difficult to treat and those requiring major operations can be closed with minimally invasive surgery. Conclusions Skin ulcers in Werner syndrome are refractory, and they lead to reduced quality of life of patients. A callosity in Werner syndrome is an important therapeutic target for the prevention of ulcers. Geriatr Gerontol Int 2021; 21: 153–159 .