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Association between uric acid and atherosclerosis in community‐dwelling older people: The SONIC study
Author(s) -
Tanaka Kentaro,
Kabayama Mai,
Sugimoto Ken,
Akasaka Hiroshi,
Takami Yoichi,
Takeya Yasushi,
Yamamoto Koichi,
Sekiguchi Toshiaki,
Kiyoshige Eri,
Akagi Yuya,
Godai Kayo,
Yasumoto Saori,
Masui Yukie,
Gondo Yasuyuki,
Ikebe Kazunori,
Arai Yasumichi,
Ishizaki Tatsuro,
Rakugi Hiromi,
Kamide Kei
Publication year - 2021
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/ggi.14081
Subject(s) - medicine , intima media thickness , uric acid , cross sectional study , correlation , risk factor , gastroenterology , carotid arteries , pathology , geometry , mathematics
Aim The association between serum uric acid (UA) and atherosclerosis in old people is controversial. Therefore, in this study, we clarified this association by assessing serum UA and common carotid atherosclerosis examined by carotid ultrasound in community‐dwelling older people in their 70s, 80s and 90s in the SONIC study. Methods A cross‐sectional study was conducted involving 538 men and 577 women recruited from the community. The analysis was performed using serum UA as the explanatory variable and the maximum carotid intima‐media thickness (max‐CIMT) and mean‐IMT as the dependent variables. The analysis was performed by multiple regression using traditional risk factors for atherosclerosis as adjustment variables. Results Analysis of the association between serum UA and IMT revealed a significant correlation only in women >70 years old. Max‐CIMT (β = 0.081, 95% CI = 0.026, 0.136; P = 0.004) and mean‐IMT (β = 0.015, 95% CI = 0.003, 0.029; P = 0.016) were significant. In the analysis of each age group, a significant correlation was only found in women in their 70s for mean‐IMT (β = 0.031, 95% CI = 0.008, 0.053; P = 0.008). Conclusion In community‐dwelling women aged about 70 years old, elevated serum UA may be an independent risk factor for IMT thickening as a surrogate marker for atherosclerosis. Geriatr Gerontol Int 2021; 21: 94–101 .