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Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome
Author(s) -
Kuzuya Masafumi,
Takemoto Minoru,
Kubota Yoshitaka,
Taniguchi Toshibumi,
Motegi SeiIchiro,
Taniguchi Akira,
Nakagami Hironori,
Maezawa Yoshiro,
Koshizaka Masaya,
Kato Hisaya,
Mori Seijiro,
Tsukamoto Kazuhisa,
Yokote Koutaro
Publication year - 2021
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/ggi.14076
Subject(s) - sarcopenia , medicine , skeletal muscle , werner syndrome , guideline , metabolic syndrome , pathology , obesity , helicase , rna , gene , biochemistry , chemistry
Aim Sarcopenia is defined as a condition that combines decreased skeletal muscle mass with weakness or decreased physical function. It is well known that in older adults, the presence of sarcopenia is a risk of frailty, falls and physical dysfunction. Patients with Werner syndrome are characterized by visceral fat accumulation and thin limbs, but the prevalence of sarcopenia in patients with Werner syndrome has not been investigated. Methods A literature search was conducted using Werner syndrome and skeletal muscle as keywords. We also analyzed data from our 7 Werner syndrome patients. Results A literature search on the relationship between Werner syndrome and skeletal muscle yielded only one article reported from Japan. According to this paper, a decrease in skeletal muscle mass (appendicular skeletal muscle index) was observed in all 9 Werner syndromes investigated. On the other hand, in our 7 Werner syndrome patients, their appendicular skeletal muscle indexes were below the standard value except for one male patient who had continued resistance exercise. Conclusion The decrease in skeletal muscle mass frequently occurs in patients with Werner syndrome. However, resistance exercise may prevent the appearance of sarcopenia and requires early intervention in patients with Werner syndrome. Geriatr Gerontol Int 2021; 21: 139–141 .