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Relationships between serum brain‐derived neurotrophic factor concentration and parameters for health scores in community‐dwelling older adults
Author(s) -
Hachisu Mitsugu,
Hashizume Masahiro,
Kawai Hisashi,
Hirano Hirohiko,
Kojima Motonaga,
Fujiwara Yoshinori,
Obuchi Shuichi,
Ihara Kazushige
Publication year - 2018
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/ggi.13210
Subject(s) - medicine , body mass index , neurotrophic factors , brain derived neurotrophic factor , sitting , grip strength , endocrinology , physical therapy , gerontology , pathology , receptor
Aim Brain‐derived neurotrophic factor (BDNF) have been implicated in the progression of neuronal survival, phenotyping differentiation and maintenance of various neurons, as well as neurogenesis. We studied how BDNF affects health parameters of older adults by carrying out a health examination of community‐dwelling older adults. Methods We measured the serum BDNF concentration of 898 older adults aged 65–84 years who participated in regional health examinations in the T okyo area and also measured various parameters, such as the thickness of the quadriceps femoris, percentage of body fat, body mass index, grip strength, frequency of walking, and use of sleeping drugs and steroidal anti‐inflammatory drugs. Results We obtained significant relationships between serum BDNF values and thickness of the quadriceps muscle, body mass index or percentage of body fat. Individuals holding onto something when they stood up had lower serum BDNF values than individuals not holding onto something when they stood up. Smokers had higher serum BDNF values than non‐smokers. Conclusions Older adults who had higher serum BDNF had bigger quadriceps muscles, higher body mass index and higher body fat rate, and were also able to stand up without holding onto something from a sitting position. Geriatr Gerontol Int 2018; 18: 456–461 .