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Altered blood flow in cerebral perforating arteries of rat models of diabetes: A synchrotron radiation microangiographic study toward clinical evaluation of white matter hyperintensities
Author(s) -
Fukuyama Naoto,
Tsukamoto Yuko,
Takizawa Shunya,
Ikeya Yoshimori,
Fujii Toshiharu,
Shinozaki Yoshiro,
Takahari Yoko,
Kawabe Noboru,
Wakaoriaki,
Umetani Keiji,
Todoroki Kikue,
Fukui Sayato,
Tanaka Chiharu,
Tanaka Etsuro,
Mori Hidezo
Publication year - 2015
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/ggi.12658
Subject(s) - microangiography , medicine , middle cerebral artery , hyperintensity , blood flow , diabetes mellitus , hemodynamics , cerebral blood flow , nuclear medicine , endocrinology , anatomy , magnetic resonance imaging , ischemia , radiology
Aim As altered blood flow in the cerebral perforating arteries ( PA ) might be related to development of cerebral white matter hyperintensities, we examined whether the hemodynamic relationship of the PA and middle cerebral artery ( MCA ) is altered in rat models of diabetes, compared with normal rats and a rat model of sinoatrial denervation (blood pressure fluctuation model). Methods We used microangiography with monochromatic synchrotron radiation to measure the diameters of the PA and MCA at 4.5 μm resolution in five groups of rats: (i) L ong‐ E vans T okushima O tsuka ( LETO ); (ii) O tsuka L ong‐ E vans T okushima F atty (a model of type 2 diabetes with obesity); (iii) LETO with sinoaortic denervation ( LETO + SAD ); (iv) F 344; and (v) F 344 + streptozotocin (a model of type 1 diabetes). Results Compared with LETO , O tsuka L ong‐ E vans T okushima F atty rats showed a significant reduction in the diameter of both PA and MCA , though the PA / MCA diameter ratio was unchanged. In contrast, compared with LETO , LETO + SAD rats showed an increased MCA diameter, and the PA / MCA diameter ratio was decreased. Compared with F 344 rats, the MCA diameter was increased in F 344 + streptozotocin rats, and the PA / MCA diameter ratio was decreased. Scatter diagrams showed that the diameters of the PA and MCA were essentially independent of each other in the two types of diabetic models. Conclusion PA were consistently visualized at high resolution by means of microangiography using synchrotron radiation. The present results show that rat diabetic models exhibit changes in PA diameter and PA / MCA diameter ratio, which might be related to the development of diabetes‐associated cerebral white matter hyperintensities. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 74–80.