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Change of carotid intima‐media thickness is associated with age in elderly J apanese patients without a history of cardiovascular disease
Author(s) -
Watanabe Kentaro,
Ouchi Motoshi,
Ohara Makoto,
Kameda Wataru,
Susa Shinji,
Oizumi Toshihide,
Wada Manabu,
Suzuki Tatsuya,
Kawanami Toru,
Oba Kenzo,
Kato Takeo
Publication year - 2015
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/ggi.12402
Subject(s) - medicine , intima media thickness , diabetes mellitus , disease , carotid ultrasonography , outpatient clinic , multivariate analysis , cardiology , carotid arteries , endocrinology
Aim The present study aimed to evaluate the relationship between the change of carotid intima‐media thickness ( CIMT ) and clinical characteristics in J apanese patients without a history of cardiovascular disease. Methods The study participants were 149 J apanese patients without a history of cardiovascular disease treated in our outpatient department. The in all participants CIMT was measured with ultrasonography at baseline and after a mean interval of 2.4 years. Study participants were divided into a middle‐aged group (younger than 65 years: n = 59) and an elderly group (65 years or older: n = 90). The annual CIMT change (Δ CIMT ) was calculated, and the associations between Δ CIMT and clinical characteristics, including age, were evaluated in both groups. Results The Δ CIMT was significantly correlated with age in all participants ( r = 0.222; P < 0.05) and in elderly participants (r = 0.234; P < 0.05), but was not correlated with other risk factors. The annual Δ CIMT was significantly higher in elderly participants (0.015 ± 0.096 mm) than in middle‐aged participants (–0.018 ± 0.088 mm; P < 0.05). Multivariate linear regression analysis with Δ CIMT as a dependent variable and risk factors as independent variables showed that Δ CIMT was significantly associated with age in all participants (β = 0.002; P < 0.05) and in elderly participants (β = 0.004; P < 0.05), but not with other risk factors. Conclusions Annual CIMT change is associated with age, rather than with other clinical characteristics, including traditional cardiovascular risk factors, such as diabetes and hypertension, in elderly J apanese patients without a history of cardiovascular disease. Geriatr Gerontol Int 2015; 15: 1023–1030.