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Systemic inflammatory impact of periodontitis on cognitive impairment
Author(s) -
Gil Montoya José Antonio,
Barrios Rocío,
SanchezLara Inés,
Ramos Pablo,
Carnero Cristobal,
Fornieles Francisco,
Montes Juan,
Santana Soraya,
Luna Juan de Dios,
GonzalezMoles Miguel Angel
Publication year - 2020
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/ger.12431
Subject(s) - medicine , periodontitis , dementia , systemic inflammation , inflammation , cognition , biomarker , cognitive impairment , disease , immunology , psychiatry , biochemistry , chemistry
Objectives The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. Methods We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. Results At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. Conclusions Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.