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Oral flora in acute stroke patients: A prospective exploratory observational study
Author(s) -
Boaden Elizabeth,
Lyons Mary,
Singhrao Sim K.,
Dickinson Hazel,
Leathley Michael,
Lightbody Catherine E.,
McLoughlin Alison,
Khan Zarine,
Crean Stjohn,
Smith Craig,
Higham Susan,
Watkins Caroline
Publication year - 2017
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/ger.12271
Subject(s) - medicine , saliva , oral cavity , stroke (engine) , carriage , flora (microbiology) , pneumonia , oral microbiome , dysphagia , dentistry , surgery , pathology , bacteria , biology , mechanical engineering , engineering , genetics
Objective To describe the bacterial profile of the oral flora during the first 2 weeks following a stroke, examining changes in the condition of the oral cavity and infections. Background Dysphagia is common after a stroke and can lead to aspiration pneumonia. Oral flora changes associated with stroke have been implicated as a possible source of bacteria that can cause systemic infections. Materials and methods Seventy‐seven participants were recruited over a period of 9 months. Fifty participants had a complete set of swabs from four different oral sites and a saliva sample taken at three time points over a 14‐day period. Molecular identification of bacteria was performed on the pooled DNA extracted. Results A total of 103 bacterial phylotypes were identified, 29 of which were not in the Human Oral Microbiome Database ( HOMD ). Fourteen of the twenty most common bacterial phylotypes found in the oral cavity were Streptococcal species with Streptococcus salivarius being the most common. The condition of the oral cavity worsened during the study period. Fifteen (30%) patients had at least one infection. Conclusions There appears to be huge diversity of bacterial organisms in the oral cavity of stroke patients, and as most phylotypes identified were only found in one or two participants, no particular patterns linked to infection or the condition of the oral cavity could be discerned.