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Fatal hepatocellular carcinoma presenting with oral metastasis in a patient with synchronic primary malignancies of prostate and liver
Author(s) -
Rodrigues Maria Fernanda Setúbal Destro,
Esteves Carina Magalhães,
Oliveira Márcio Augusto,
Andrade Nathália Paiva,
Sedassari Bruno Tavares,
Soares Fernando Augusto,
Nunes Fabio Daumas
Publication year - 2017
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/ger.12236
Subject(s) - medicine , hepatocellular carcinoma , metastasis , cytokeratin , pathology , carcinoma , primary tumor , cancer , prostate , prostate cancer , oncology , immunohistochemistry
Background Hepatocellular carcinoma ( HCC ) is the most frequent type of liver cancer and its occurrence in the oral cavity as a metastatic neoplasm is a rare event. We describe a fatal case of HCC with oral metastasis in a patient firstly diagnosed with prostatic and hepatic carcinomas. The histopathological examination revealed a hepatocyte‐like tumour cells arranged in organoid structures as well as positivity to cytokeratin 8 and Hep Par 1. The present findings highlight the importance of a complete medical evaluation of the patient to identify possible oral repercussions of primary diseases.