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Cystatin C ‐based estimated glomerular filtration rate and periodontitis
Author(s) -
Iwasaki Masanori,
Taylor George W.,
Sato Misuzu,
Nakamura Kazutoshi,
Yoshihara Akihiro,
Miyazaki Hideo
Publication year - 2016
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/ger.12159
Subject(s) - medicine , renal function , cystatin c , periodontitis , poisson regression , confidence interval , creatinine , cystatin , urology , gastroenterology , population , environmental health
Background and Objective Accumulating evidence suggests that decreased kidney function characterised by low estimated glomerular filtration rate ( eGFR ) may be associated with periodontitis. Recent studies have suggested that the use of cystatin C strengthens the association between the eGFR and the risks of adverse outcomes in decreased kidney function. The aim of this cross‐sectional study was to investigate the association of cystatin C‐based eGFR ( eGFR cys) and creatinine‐based eGFR ( eGFR creat), the commonly used method to assess kidney function, with periodontitis in 502 Japanese women (average age, 68.6 years). Materials and Methods GFR was estimated from serum cystatin C and serum creatinine, respectively, using the Japanese equation for GFR. Participants were classified into five groups according to their eGFR cys and eGFR creat values. Poisson regression models with robust error variance assessed the associations of eGFR cys and eGFR creat with periodontitis. Tests for trends were performed by fitting the five‐category eGFR variables in their continuous form to the regression models. Results Participants with eGFR cys < 50 ml/min/1.73 m 2 were at significantly higher risk of periodontitis compared with the reference group (≥90 ml/min/1.73 m 2 ) (adjusted relative risk = 2.12, 95% confidence interval = 1.12 to 4.02). Additionally, there was a trend towards a higher risk of periodontitis among participants with lower eGFR cys values ( p for trend in the multivariable model = 0.008). In contrast, eGFR creat did not show a significant association with periodontitis. Conclusion The findings of this study of Japanese older women showed that eGFR cys had a stronger and more linear association with periodontitis than eGFR creat.