Premium
Canalicular adenoma immunoprofile: a case report
Author(s) -
Sivolella Stefano,
Valente Marialuisa,
Biagi Marleen,
Mazzoleni Sergio,
Stellini Edoardo
Publication year - 2014
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/ger.12039
Subject(s) - medicine , myoepithelial cell , immunohistochemistry , pathology , malignancy , differential diagnosis , cytokeratin , histology , salivary gland , pleomorphic adenoma , adenoma , lesion
Objectives To report a case of canalicular adenoma (CA) and discuss the use of immunohistochemistry to better address the diagnosis given some unusual characteristics in this patient. Background CA is an uncommon benign neoplasm that can develop in minor salivary gland duct tissues throughout the oral cavity. At histology, it shares several features with other salivary tumors. Immunohistochemistry can be useful in the differential diagnosis. Materials and methods The clinical presentation consisted in a nodule on the left upper lip of an 85‐year‐old man. The patient's main complaint was upper denture instability secondary to soft tissue changes. The nodule was excised under local anesthesia and underwent histological and immunohistochemical examination to rule out any malignancy. Results Histological findings, cytokeratin positivity and the absence of any reactivity to specific markers of myoepithelial differentiation confirmed the epithelial nature of the lesion. Conclusion The histological diagnosis of benign salivary tumors such as CA can be confirmed by immunohistochemistry