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Age‐related changes in rat genioglossus, geniohyoid and masseter muscles
Author(s) -
Kaneko Syuhei,
Iida Ryohei,
Suga Takeo,
Morito Mitsuhiko,
Yamane Akira
Publication year - 2014
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/ger.12004
Subject(s) - genioglossus , ageing , medicine , anatomy , myosin , craniofacial , masseter muscle , endocrinology , tongue , biology , microbiology and biotechnology , pathology , psychiatry
Objectives The aim of this study was to elucidate age‐related changes from adult to middle age in the contractile properties of the masseter, genioglossus and geniohyoid muscles of the rat. Materials and Methods We analysed the expressions of myosin heavy chain ( M y HC ) m RNA s and proteins as indicators of the contractile properties in these muscles obtained from rats at 6, 12, 18 and 24 months of age using real‐time PCR and SDS ‐ PAGE . Results We found no marked age‐related changes in the expressions of M y HC m RNA s and proteins in rat masseter and geniohyoid muscles, suggesting that the biological ageing process does not affect contractile properties in these muscles. However, we found a decrease in the expression of M y HC II b m RNA with ageing in the rat genioglossus muscle, suggesting that biological ageing process induces at least some fast‐to‐slow myofibre phenotype transition. Conclusion The biological ageing process from adult to middle age appears to differentially affect different types of craniofacial muscles.