Open AccessBeyond the response—High throughput behavioral analyses to link genome to phenome in Caenorhabditis elegans
Author(s) -
McDiarmid T. A.,
Yu A. J.,
Rankin C. H.
Publication year - 2018
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/gbb.12437
Subject(s) - phenome , caenorhabditis elegans , behavioural genetics , biology , computational biology , genome , behavioral modeling , neuroscience , evolutionary biology , computer science , genetics , artificial intelligence , gene
An illustration of classic manual stop‐framed video analysis of a simple behavior—the Caenorhabditis elegans tap withdrawal response. A, A single C. elegans worm crawling on agar in a petri plate. A push solenoid (bottom left) delivers a mechanosensory tap stimulus that vibrates the agar, causing the worm to reverse. The probability and distance of the reversal response is manually scored by tracing the trajectory of the worm on to acetate sheets using stop‐framed video analysis. B, With repeated stimulation the probability of the response habituates (observed as a gradually learned response decrement). Error bars denote SEM.