Open AccessCDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice
Author(s) -
Sivilia S.,
Mangano C.,
Beggiato S.,
Giuliani A.,
Torricella R.,
Baldassarro V. A.,
Fernandez M.,
Lorenzini L.,
Giardino L.,
Borelli A. C.,
Ferraro L.,
Calzà L.
Publication year - 2016
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/gbb.12292
Subject(s) - cerebellum , glutamatergic , glutamate receptor , excitatory postsynaptic potential , inhibitory postsynaptic potential , motor coordination , gabaergic , knockout mouse , biology , neuroscience , hippocampus , endocrinology , medicine , chemistry , receptor , biochemistry
CDKL5 deletion impairs the establishment of a correct GABA ‐ and glutamatergic cerebellar network, leading to locomotion abnormalities.