Open AccessIdentification of quantitative trait loci and candidate genes for an anxiolytic‐like response to ethanol in BXD recombinant inbred strains
Author(s) -
Putman A. H.,
Wolen A. R.,
Harenza J. L.,
Yordanova R. K.,
Webb B. T.,
Chesler E. J.,
Miles M. F.
Publication year - 2016
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/gbb.12289
Subject(s) - quantitative trait locus , nucleus accumbens , genetics , anxiolytic , biology , candidate gene , locus (genetics) , inbred strain , ventral tegmental area , prefrontal cortex , gene , neuroscience , dopamine , cognition , receptor , dopaminergic
Behavioral genetics and genomic studies were identified as a novel locus modulating anxiolytic‐like activity of ethanol in mice. We validated and fine mapped the most significant ethanol‐anxiolytic QTL on Chr 12, termed Etanq1 , and identified a highly promising candidate gene, Ninein . This is a very novel finding and because anxiety is considered a strong co‐morbid factor for the development of alcohol use disorders and recidivism, we believe our studies are highly significant.