Identification of quantitative trait loci and candidate genes for an anxiolytic‐like response to ethanol in  BXD  recombinant inbred strains | Zendy

Putman A. H. | Zendy; Wolen A. R. | Zendy; Harenza J. L. | Zendy; Yordanova R. K. | Zendy; Webb B. T. | Zendy; Chesler E. J. | Zendy; Miles M. F. | Zendy

Open Access

Identification of quantitative trait loci and candidate genes for an anxiolytic‐like response to ethanol in BXD recombinant inbred strains

Author(s) -

Putman A. H.,

Wolen A. R.,

Harenza J. L.,

Yordanova R. K.,

Webb B. T.,

Chesler E. J.,

Miles M. F.

Publication year - 2016

Publication title -

genes, brain and behavior

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 91

eISSN - 1601-183X

pISSN - 1601-1848

DOI - 10.1111/gbb.12289

Subject(s) - quantitative trait locus , nucleus accumbens , genetics , anxiolytic , biology , candidate gene , locus (genetics) , inbred strain , ventral tegmental area , prefrontal cortex , gene , neuroscience , dopamine , cognition , receptor , dopaminergic

Behavioral genetics and genomic studies were identified as a novel locus modulating anxiolytic‐like activity of ethanol in mice. We validated and fine mapped the most significant ethanol‐anxiolytic QTL on Chr 12, termed Etanq1 , and identified a highly promising candidate gene, Ninein . This is a very novel finding and because anxiety is considered a strong co‐morbid factor for the development of alcohol use disorders and recidivism, we believe our studies are highly significant.

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