Open AccessIntegrated circuits and molecular components for stress and feeding: implications for eating disorders
Author(s) -
Hardaway J. A.,
Crowley N. A.,
Bulik C. M.,
Kash T. L.
Publication year - 2015
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/gbb.12185
Subject(s) - eating disorders , anorexia nervosa , bulimia nervosa , anxiety , psychology , binge eating disorder , anorexia , binge eating , neuroscience , biological neural network , clinical psychology , disease , fight or flight response , etiology , psychiatry , medicine , biology , genetics , gene , pathology
Eating disorders are complex brain disorders that afflict millions of individuals worldwide. The etiology of these diseases is not fully understood, but a growing body of literature suggests that stress and anxiety may play a critical role in their development. As our understanding of the genetic and environmental factors that contribute to disease in clinical populations like anorexia nervosa, bulimia nervosa and binge eating disorder continue to grow, neuroscientists are using animal models to understand the neurobiology of stress and feeding. We hypothesize that eating disorder clinical phenotypes may result from stress‐induced maladaptive alterations in neural circuits that regulate feeding, and that these circuits can be neurochemically isolated using animal model of eating disorders.