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Fatty acid metabolism in adaptive immunity
Author(s) -
Zhou Xian,
Zhu Xingxing,
Zeng Hu
Publication year - 2023
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.16296
Subject(s) - immune system , acquired immune system , immunity , biology , metabolism , fatty acid metabolism , computational biology , fatty acid , biochemistry , cell metabolism , microbiology and biotechnology , chemistry , immunology
Fatty acids (FAs) not only are a key component of cellular membrane structure, but also have diverse functions in biological processes. Recent years have seen great advances in understanding of how FA metabolism contributes to adaptive immune response. Here, we review three key processes, FA biosynthesis, FA oxidation and FA uptake, and how they direct T and B cell functions during immune challenges. Then, we will focus on the relationship between microbiota derived FAs, short‐chain FAs, and adaptive immunity. Along the way, we will also discuss the outstanding controversies and challenges in the field.