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LRRK2 recruitment, activity, and function in organelles
Author(s) -
BonetPonce Luis,
Cookson Mark R.
Publication year - 2022
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.16099
Subject(s) - lrrk2 , organelle , microbiology and biotechnology , leucine rich repeat , phenotype , kinase , intracellular , biology , gene , chromosomal translocation , transport protein , genetics , mutation
Protein coding mutations in leucine‐rich repeat kinase 2 ( LRRK2 ) cause familial Parkinson’s disease (PD), and noncoding variations around the gene increase the risk of developing sporadic PD. It is generally accepted that pathogenic LRRK2 mutations increase LRRK2 kinase activity, resulting in a toxic hyperactive protein that is inferred to lead to the PD phenotype. LRRK2 has long been linked to different membrane trafficking events, but the specific role of LRRK2 in these events has been difficult to resolve. Recently, several papers have reported the activation and translocation of LRRK2 to cellular organelles under specific conditions, which suggests that LRRK2 may influence intracellular membrane trafficking. Here, we review what is known about the role of LRRK2 at various organelle compartments.