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The role of the Hippo pathway in heart disease
Author(s) -
Xie Jiahong,
Wang Yuxin,
Ai Ding,
Yao Liu,
Jiang Hongfeng
Publication year - 2022
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.16092
Subject(s) - hippo signaling pathway , regeneration (biology) , heart failure , disease , myocardial infarction , diabetic cardiomyopathy , coronary artery disease , heart disease , medicine , muscle hypertrophy , cardiology , biology , microbiology and biotechnology , signal transduction , cardiomyopathy
Heart disease, including coronary artery disease, myocardial infarction, heart failure, cardiac hypertrophy, and cardiomyopathies, is the leading causes of death worldwide. The Hippo pathway is a central controller for organ size and tissue growth, which plays a pivotal role in determining cardiomyocytes and nonmyocytes proliferation, regeneration, differentiation, and apoptosis. In this review, we summarize the effects of the Hippo pathway on heart disease and propose potential intervention targets. Especially, we discuss the molecular mechanisms of the Hippo pathway involved in maintaining cardiac homeostasis by regulating cardiomyocytes and nonmyocytes function in the heart. Based on this, we conclude that the Hippo pathway is a promising therapeutic target for cardiovascular therapy, which will bring new perspectives for their treatments.