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Interpreting the role of the striatum during multiple phases of motor learning
Author(s) -
Cataldi Stefano,
Stanley Adrien T.,
Miniaci Maria Concetta,
Sulzer David
Publication year - 2022
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15908
Subject(s) - striatum , neuroscience , motor learning , basal ganglia , motor skill , psychology , motor control , procedural memory , cognition , motor function , motor behavior , action selection , biology , central nervous system , dopamine , medicine , physical medicine and rehabilitation , perception
The synaptic pathways in the striatum are central to basal ganglia functions including motor control, learning and organization, action selection, acquisition of motor skills, cognitive function, and emotion. Here, we review the role of the striatum and its connections in motor learning and performance. The development of new techniques to record neuronal activity and animal models of motor disorders using neurotoxin, pharmacological, and genetic manipulations are revealing pathways that underlie motor performance and motor learning, as well as how they are altered by pathophysiological mechanisms. We discuss approaches that can be used to analyze complex motor skills, particularly in rodents, and identify specific questions central to understanding how striatal circuits mediate motor learning.