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ID1 inhibits foot‐and‐mouth disease virus replication via targeting of interferon pathways
Author(s) -
Ren Tingting,
Chen Haotai,
Liu Xinsheng,
Wang Yanxue,
Fan Aixia,
Qi Linlin,
Pan Li,
Bai Wenlong,
Zhang Yongguang,
Sun Yuefeng
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15725
Subject(s) - interferon , biology , foot and mouth disease virus , transcription factor , virus , foxo1 , viral replication , ubiquitin , irf1 , virology , transcription (linguistics) , cancer research , gene , genetics , philosophy , linguistics
Inhibitor of DNA‐binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance of stem cell‐like properties, but its roles in virus infection are less understood. In the present study, we have clearly shown that the foot‐and‐mouth disease virus (FMDV) promotes ID1 degradation via Cdh1‐mediated ubiquitination to facilitate its replication. Mechanistic investigations reveal Forkhead Box O1 (FOXO1) as an ID1 partner, which suppresses interferon regulatory factors 3 expression and interferon (IFN) production. Further investigation identified that ID1 suppresses FOXO1 transcription activity through HDAC4‐mediated deacetylation, promoting IFN production and antiviral immune response. These studies establish a prominent role for ID1 in suppressing FDMV replication, which may be extended to other viruses.