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Translation initiation and its relevance in colorectal cancer
Author(s) -
Minnee Emma,
Faller William James
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15690
Subject(s) - reprogramming , translation (biology) , translational regulation , pi3k/akt/mtor pathway , biology , wnt signaling pathway , cancer , eukaryotic translation , tumor initiation , translational efficiency , colorectal cancer , cancer research , translational research , signal transduction , genetics , microbiology and biotechnology , gene , messenger rna , carcinogenesis
Protein synthesis is one of the most essential processes in every kingdom of life, and its dysregulation is a known driving force in cancer development. Multiple signaling pathways converge on the translation initiation machinery, and this plays a crucial role in regulating differential gene expression. In colorectal cancer, dysregulation of initiation results in translational reprogramming, which promotes the selective translation of mRNAs required for many oncogenic processes. The majority of upstream mutations found in colorectal cancer, including alterations in the WNT, MAPK, and PI3K\AKT pathways, have been demonstrated to play a significant role in translational reprogramming. Many translation initiation factors are also known to be dysregulated, resulting in translational reprogramming during tumor initiation and/or maintenance. In this review, we outline the role of translational reprogramming that occurs during colorectal cancer development and progression and highlight some of the most critical factors affecting the etiology of this disease.