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Functional non‐coding RNAs in vascular diseases
Author(s) -
Ono Koh,
Horie Takahiro,
Baba Osamu,
Kimura Masahiro,
Tsuji Shuhei,
Rodriguez Randolph Ruiz,
Miyagawa Sawa,
Kimura Takeshi
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15678
Subject(s) - computational biology , biology , computer science
Recently, advances in genomic technology such as RNA sequencing and genome‐wide profiling have enabled the identification of considerable numbers of non‐coding RNAs (ncRNAs). MicroRNAs have been studied for decades, leading to the identification of those with disease‐causing and/or protective effects in vascular disease. Although other ncRNAs such as long ncRNAs have not been fully described yet, recent studies have indicated their important functions in the development of vascular diseases. Here, we summarize the current understanding of the mechanisms and functions of ncRNAs, focusing on microRNAs, circular RNAs and long ncRNAs in vascular diseases.

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