Premium
Genome‐scale molecular principles of mRNA half‐life regulation in yeast
Author(s) -
Basu Sudipto,
Mallik Saurav,
Hait Suman,
Kundu Sudip
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15670
Subject(s) - messenger rna , biology , endoribonuclease , rnase p , ribonucleoprotein , messenger rnp , rna , p bodies , genetics , gene , computational biology , microbiology and biotechnology , translation (biology)
Precise control of protein and mRNA degradation is essential for cellular metabolism and homeostasis. Although the molecular factors governing protein degradation have been elucidated across multiple organisms, our mechanistic understanding of mRNA degradation remains incomplete. Here, Sudipto Basu and colleagues analyzed multiple genome‐scale experimental yeast mRNA half‐life data in light of experimentally derived mRNA secondary structures and protein binding data, along with high‐resolution X‐ray crystallographic structures of RNase machines. The authors revealed that the relative abundance of unstructured and structured segments within the transcripts influences mRNA half‐life on a genome scale, highlighting remarkable similarities with the principles underlying protein degradation.