Alveolar epithelial cell‐derived Sonic hedgehog promotes pulmonary fibrosis through OPN‐dependent alternative macrophage activation | Zendy

Hou Jiwei | Zendy; Ji Jie | Zendy; Chen Xiang | Zendy; Cao Honghui | Zendy; Tan Yi | Zendy; Cui Yu | Zendy; Xiang Zou | Zendy; Han Xiaodong | Zendy

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Alveolar epithelial cell‐derived Sonic hedgehog promotes pulmonary fibrosis through OPN‐dependent alternative macrophage activation

Author(s) -

Hou Jiwei,

Ji Jie,

Chen Xiang,

Cao Honghui,

Tan Yi,

Cui Yu,

Xiang Zou,

Han Xiaodong

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15669

Subject(s) - paracrine signalling , sonic hedgehog , pulmonary fibrosis , macrophage , cancer research , fibrosis , macrophage polarization , autocrine signalling , microbiology and biotechnology , biology , immunology , pathology , signal transduction , medicine , receptor , biochemistry , in vitro

Alveolar epithelial cell‐derived Sonic hedgehog (Shh) promotes pulmonary fibrosis through osteopontin (OPN)‐dependent alternative macrophage activation. Fibrosis‐associated ATII cells secrete Shh, a hedgehog pathway ligand, and that ATII cell‐derived Shh promotes the secretion of OPN in macrophages via Shh/Gli signaling cascade. The secreted OPN acts on the surrounding macrophages in an autocrine or paracrine manner and induces macrophage alternative activation through activating the JAK2/STAT3 signaling pathway, eventually leading to pulmonary fibrogenesis.

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