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Influenza A virus infection‐induced macroautophagy facilitates MHC class II‐restricted endogenous presentation of an immunodominant viral epitope
Author(s) -
Deng Jieru,
Lu Chunni,
Liu Chuanxin,
Oveissi Sara,
Fairlie W. Douglas,
Lee Erinna F.,
Bilsel Pamuk,
Puthalakath Hamsa,
Chen Weisan
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15654
Subject(s) - mhc class i , antigen presentation , biology , antigen processing , cross presentation , major histocompatibility complex , antigen , epitope , virology , mhc class ii , mhc restriction , microbiology and biotechnology , immunology , t cell , immune system
Whether influenza A virus (IAV) infection‐induced macroautophagy leads to endogenous antigen presentation via MHC‐II is still debated. Here, Weisan Chen and colleagues demonstrate that IAV infection‐induced autophagosome formation promotes MHC‐II‐restricted endogenous IAV antigen presentation. This process requires de novo antigen/MHC‐II synthesis, is enhanced by cytosolic peptide accumulation and is inhibited by autophagy inhibitors and autophagy gene deletion. Fusion of the autophagosomes with MHC Class II compartment (MIIC) likely promotes endogenous IAV antigen presentation by MHC‐II to CD4 + T cells. These results provide strong evidence that IAV infection‐induced macroautophagy facilitates endogenous IAV antigen presentation by MHC‐II to CD4 + T cells.