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From cell surface to signalling and back: the life of the mammalian FSH receptor
Author(s) -
Banerjee Antara A.,
Joseph Shaini,
Mahale Smita D.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15649
Subject(s) - follicle stimulating hormone receptor , receptor , biology , signal transduction , microbiology and biotechnology , hormone receptor , autocrine signalling , 5 ht5a receptor , cell surface receptor , follicle stimulating hormone , medicine , luteinizing hormone , endocrinology , hormone , genetics , cancer , breast cancer
Follicle‐stimulating hormone receptor (FSHR) plays a central role in mammalian reproduction. After synthesis, FSHR undergoes post‐translational modifications and trafficks to the cell surface followed by FSH binding and subsequent signal transduction events, FSH–FSHR internalization, and recycling or degradation of FSH–FSHR complexes. This journey of FSHR is regulated at various check points and dysfunctions at these check points result in reproductive pathophysiologies.