Beyond energy storage: roles of glycogen metabolism in health and disease | Zendy

Zhang Huafeng | Zendy; Ma Jingwei | Zendy; Tang Ke | Zendy; Huang Bo | Zendy

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Beyond energy storage: roles of glycogen metabolism in health and disease

Author(s) -

Zhang Huafeng,

Ma Jingwei,

Tang Ke,

Huang Bo

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15648

Subject(s) - glycogen , glycogenolysis , glycogenesis , biology , glycogen storage disease , glycogen synthase , microbiology and biotechnology , glycogen storage disease type i , gluconeogenesis , glycolysis , metabolism , biochemistry

This review discusses the roles of glycogen from a new perspective beyond storing and supplying energy. We discuss the role of UDPG as a signal molecule beyond transferring glucose to glycogen. Furthermore, we emphasize the critical role of the gluconeogenesis‐glycogenesis‐glycogenolysis‐PPP metabolic chain in redox homeostasis and discuss how the metabolic chain affects CD8 + T‐cell memory formation, macrophage polarization, and tumor‐repopulating cell growth.

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