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Beyond energy storage: roles of glycogen metabolism in health and disease
Author(s) -
Zhang Huafeng,
Ma Jingwei,
Tang Ke,
Huang Bo
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15648
Subject(s) - glycogen , glycogenolysis , glycogenesis , biology , glycogen storage disease , glycogen synthase , microbiology and biotechnology , gluconeogenesis , metabolism , biochemistry
This review discusses the roles of glycogen from a new perspective beyond storing and supplying energy. We discuss the role of UDPG as a signal molecule beyond transferring glucose to glycogen. Furthermore, we emphasize the critical role of the gluconeogenesis‐glycogenesis‐glycogenolysis‐PPP metabolic chain in redox homeostasis and discuss how the metabolic chain affects CD8 + T‐cell memory formation, macrophage polarization, and tumor‐repopulating cell growth.