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Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts
Author(s) -
Farah Hussein,
Young Stephen P.,
Mauro Claudio,
Jones Simon W.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15644
Subject(s) - inflammation , stromal cell , fibrosis , immune system , fibroblast , immunology , medicine , cancer research , disease , mesenchymal stem cell , tumor microenvironment , biology , pathology , cell culture , genetics
Stromal fibroblasts are central mediators of chronic inflammatory disease. Changes to fibroblast metabolism (including glycolysis, oxidative phosphorylation, pentose phosphate pathway, glutamine metabolism and lactate transport) fuels and underpins the switch in fibroblast phenotype towards an inflammatory‐activated phenotype that drives chronic inflammation. Cancer‐associated fibroblasts drive tumour progression, activated synoviocytes drive joint inflammation, and activated myoblasts drive fibrotic disorders including chronic kidney disease, pulmonary fibrosis, heart disease and liver disease.