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Molecular and spatial mechanisms governing STING signalling
Author(s) -
Balka Katherine R.,
De Nardo Dominic
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15640
Subject(s) - sting , stimulator of interferon genes , irf3 , innate immune system , microbiology and biotechnology , proinflammatory cytokine , biology , signalling pathways , signalling , interferon regulatory factors , signal transduction , transcription factor , tank binding kinase 1 , immune system , immunology , inflammation , genetics , gene , mapk/erk pathway , engineering , aerospace engineering , map kinase kinase kinase
The cGAS‐STING pathway generates a host immune response against pathogens. cGAS‐STING activation induces the production of antiviral type I IFNs and proinflammatory cytokines via transcription factors IRF3 and NF‐κB, respectively. This review provides a comprehensive overview of the signalling events and intracellular trafficking processes that mediate STING inflammatory responses and further highlights emerging and intriguing concepts within the cGAS‐STING field.

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