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The multifaceted role of TRAIL signaling in cancer and immunity
Author(s) -
Cardoso Alves Ludmila,
Corazza Nadia,
Micheau Olivier,
Krebs Philippe
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15637
Subject(s) - tumor necrosis factor alpha , immune system , biology , signal transduction , cancer , apoptosis , cancer cell , microbiology and biotechnology , function (biology) , immunology , cancer research , genetics
Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a ligand first described for its pro‐apoptotic function. Recent evidence shows that TRAIL may also trigger diverse nonapoptotic signals in tumor and nontransformed cells, as exemplified in this cartoon for natural killer (NK) cells. This review discusses the current knowledge on such noncanonical TRAIL signaling in immune and malignant cells and the consequences thereof for a therapeutic manipulation of TRAIL in cancer.