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PARP1 and PRC2 double deficiency promotes BRCA ‐proficient breast cancer growth by modification of the tumor microenvironment
Author(s) -
Yang AYeong,
Choi EunBee,
So Park Mi,
Kim SeonKyu,
Park MinSeok,
Kim MiYoung
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15636
Subject(s) - parp1 , cancer research , tumor microenvironment , triple negative breast cancer , prc2 , poly adp ribose polymerase , angiogenesis , dna damage , cancer , biology , breast cancer , chemistry , ezh2 , polymerase , dna , chromatin , genetics , tumor cells
Poly (ADP‐ribose) polymerase 1 (PARP1) and polycomb repressive complex 2 (PRC2) have important individual roles in the development of cancer. In BRCA ‐mutant breast cancers, research on the co‐operation of these two factors has focused on the DNA damage repair process; however, how they cooperate to modulate the tumor microenvironment remains unclear. Here, Mi‐Young Kim and colleagues show that simultaneous inhibition of PARP1 and PRC2 in BRCA ‐proficient triple negative breast cancer leads to enhanced angiogenesis and macrophage differentiation. The authors reveal a previously unknown synthetic viable interaction between PARP1 and PRC2 that results in a NF‐κB‐mediated modification of the tumor microenvironment.