Premium
PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis
Author(s) -
Li XiaoHan,
Ju JiaQian,
Pan ZhenNan,
Wang HongHui,
Wan Xiang,
Pan MengHao,
Xu Yao,
Sun MingHong,
Sun ShaoChen
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15634
Subject(s) - midbody , microbiology and biotechnology , cytokinesis , anaphase , telophase , meiosis ii , biology , meiosis , mitosis , spindle apparatus , oocyte , genetics , cell division , cell cycle , embryo , cell , gene
Protein regulator of cytokinesis 1 (PRC1) colocalizes with microtubules in mouse oocytes, and PRC1 is essential for microtubule stability through its effects on tubulin acetylation. PRC1 regulates midzone and midbody formation, which further involves into cytokinesis under the regulation of KIF4A in mouse oocytes.