Going up the hill: chromatin‐based barriers to epigenetic reprogramming | Zendy

Arabacı Dilşad H. | Zendy; Terzioğlu Gizem | Zendy; Bayırbaşı Büşra | Zendy; Önder Tamer T. | Zendy

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Going up the hill: chromatin‐based barriers to epigenetic reprogramming

Author(s) -

Arabacı Dilşad H.,

Terzioğlu Gizem,

Bayırbaşı Büşra,

Önder Tamer T.

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15628

Subject(s) - reprogramming , chromatin , epigenetics , microbiology and biotechnology , biology , computational biology , genetics , dna , gene

Reprogramming of somatic cells to pluripotency is a remarkable process in which epigenetic mechanisms that safeguard differentiated cell states must be overcome. Both activation‐associated and repressive chromatin factors have emerged as major barriers to reprogramming. Genetic or chemical manipulation of these factors enhances the kinetics and efficiency of reprogramming and helps generate induced pluripotent stem cells (iPSCs) for use in disease modeling and cell‐based therapies.

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