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Going up the hill: chromatin‐based barriers to epigenetic reprogramming
Author(s) -
Arabacı Dilşad H.,
Terzioğlu Gizem,
Bayırbaşı Büşra,
Önder Tamer T.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15628
Subject(s) - reprogramming , biology , chromatin , epigenomics , epigenetics , bivalent chromatin , microbiology and biotechnology , chromatin remodeling , histone code , histone , somatic cell nuclear transfer , dna methylation , somatic cell , genetics , nucleosome , gene expression , gene , embryo , embryogenesis , blastocyst
Reprogramming of somatic cells to pluripotency is a remarkable process in which epigenetic mechanisms that safeguard differentiated cell states must be overcome. Both activation‐associated and repressive chromatin factors have emerged as major barriers to reprogramming. Genetic or chemical manipulation of these factors enhances the kinetics and efficiency of reprogramming and helps generate induced pluripotent stem cells (iPSCs) for use in disease modeling and cell‐based therapies.