Premium
Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification
Author(s) -
Yu Shi,
Green Jack,
Wellens Rose,
LopezCastejon Gloria,
Brough David
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15619
Subject(s) - inflammasome , bafilomycin , microbiology and biotechnology , chemistry , extracellular , lysosome , caspase 1 , atpase , autophagy , biochemistry , biology , enzyme , apoptosis , receptor
The NLRP3 inflammasome drives inflammation in response to tissue damage and infection by promoting the processing and release of IL‐1β. Human monocytes have an alternative pathway of NLRP3 inflammasome activation in response to lipopolysaccharide alone. Here, we report that the vacuolar ATPase, a lysosomal proton pump, is a regulator of the alternative NLRP3 response.