Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification | Zendy

Yu Shi | Zendy; Green Jack | Zendy; Wellens Rose | Zendy; LopezCastejon Gloria | Zendy; Brough David | Zendy

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Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

Author(s) -

Yu Shi,

Green Jack,

Wellens Rose,

LopezCastejon Gloria,

Brough David

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15619

Subject(s) - inflammasome , bafilomycin , microbiology and biotechnology , extracellular , chemistry , caspase 1 , lysosome , atpase , autophagy , biochemistry , biology , enzyme , apoptosis , receptor

The NLRP3 inflammasome drives inflammation in response to tissue damage and infection by promoting the processing and release of IL‐1β. Human monocytes have an alternative pathway of NLRP3 inflammasome activation in response to lipopolysaccharide alone. Here, we report that the vacuolar ATPase, a lysosomal proton pump, is a regulator of the alternative NLRP3 response.

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