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Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue
Author(s) -
Dommerholt Marleen B.,
Blankestijn Maaike,
VieiraLara Marcel A.,
van Dijk Theo H.,
Wolters Henk,
Koster Mirjam H.,
Gerding Albert,
van Os Ronald P.,
Bloks Vincent W.,
Bakker Barbara M.,
Kruit Janine K.,
Jonker Johan W.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15604
Subject(s) - fgf21 , endocrinology , medicine , white adipose tissue , brown adipose tissue , adipose tissue , biology , insulin resistance , thermogenesis , thermogenin , obesity , fibroblast growth factor , receptor
A reduced dietary protein intake has been demonstrated to improve metabolic health under various conditions. Here, it is shown that a short‐term 7% low‐protein dietary intervention can impact age‐related metabolic health in 18‐month‐old animals. Alongside increased plasma fibroblast growth factor 21 levels, a low‐protein diet induces energy expenditure and browning of white adipose tissue in 18‐month‐old mice, without negatively affecting muscle strength.