Premium
The lysosomal membrane—export of metabolites and beyond
Author(s) -
Rudnik Sönke,
Damme Markus
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15602
Subject(s) - lysosome , organelle , microbiology and biotechnology , golgi apparatus , cytoplasm , catabolism , function (biology) , membrane transport protein , membrane contact site , biochemistry , membrane transport , compartment (ship) , biology , membrane , membrane protein , integral membrane protein , chemistry , cell , metabolism , enzyme , oceanography , geology
Lysosomes are degradative organelles in eukaryotic cells mediating the hydrolytic catabolism of various macromolecules to small basic building blocks that are transported across the lysosomal membrane and reused in the cytoplasm for biosynthetic pathways. We review the current knowledge about the lysosomal membrane and identify some of the open questions to be addressed for a comprehensive and complete understanding of how lysosomes communicate with other organelles, cellular processes, and pathways.