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Escaping the Lion’s Den: redirecting autophagy for unconventional release and spread of viruses
Author(s) -
Teo Qi Wen,
Leur Sophie Wilhelmina,
Sanyal Sumana
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15590
Subject(s) - autophagy , microbiology and biotechnology , biology , intracellular , secretion , cytosol , biochemistry , apoptosis , enzyme
RNA virus progenies undergo secretion and spread via multiple pathways. We highlight recent evidence on the autophagosome‐derived unconventional route. The inner membrane of these organelles can either disintegrate to release free virions or stay intact to release populations of virions in membrane‐bound forms, which are then internalized into neighboring cells by distinct entry mechanisms.