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NET formation – mechanisms and how they relate to other cell death pathways
Author(s) -
Rosazza Thibault,
Warner Jordan,
Sollberger Gabriel
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15589
Subject(s) - necroptosis , pyroptosis , programmed cell death , crosstalk , microbiology and biotechnology , lytic cycle , apoptosis , extracellular , neutrophil extracellular traps , biology , chromatin , cell , autophagy , inflammation , chemistry , immunology , biochemistry , dna , virus , physics , optics
Neutrophils are able to release their chromatin, decorated with antimicrobial proteins, to the extracellular space in a process called formation of neutrophil extracellular traps (NETs). NETs can be formed via neutrophil lysis or released from viable neutrophils. They capture extracellular microbes but are also harmful to the host. Here, we discuss mechanisms of NET formation and how they relate to other forms of cell death.