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Metabolic heterogeneity of human hepatocellular carcinoma: implications for personalized pharmacological treatment
Author(s) -
Berndt Nikolaus,
Eckstein Johannes,
Heucke Niklas,
Wuensch Tilo,
Gajowski Robert,
Stockmann Martin,
Meierhofer David,
Holzhütter HermannGeorg
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15587
Subject(s) - metabolic pathway , biology , hccs , urea cycle , metabolism , hepatocellular carcinoma , metabolomics , cancer research , warburg effect , glutamine , biochemistry , glycolysis , bioinformatics , amino acid , arginine
.We created instantiations of the comprehensive kinetic model of liver metabolism (HEPATOKIN1) for individual hepatocellular carcinoma (HCC) by using protein intensities obtained by quantitative proteomics to scale enzyme activities. Model simulations reveal a large heterogeneity of HCC metabolism, which entails large individual differences in the efficacy of anticancer drugs like metformin. In the majority of HCC, the Warburg effect was absent