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The characteristics and roles of β‐TrCP1/2 in carcinogenesis
Author(s) -
Bi Yanli,
Cui Danrui,
Xiong Xiufang,
Zhao Yongchao
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15585
Subject(s) - ubiquitin ligase , ubiquitin , signal transducing adaptor protein , carcinogenesis , f box protein , cullin , scaffold protein , biology , skp1 , microbiology and biotechnology , context (archaeology) , ubiquitin protein ligases , cancer research , suppressor , signal transduction , cancer , biochemistry , genetics , gene , paleontology
SCF β‐TrCP ubiquitin ligase plays a critical role in the regulation of various physiological and pathological processes by governing key regulators for ubiquitination and proteasomal degradation. Its activity is tightly controlled at multiple layers, including multiple signaling pathways, miRNAs, and lncRNAs. A variety of β‐TrCP substrates are well‐known oncoproteins and tumor suppressors, and dysregulation of β‐TrCP is frequently identified in human cancers. Therefore, β‐TrCP plays cellular context‐dependent tumor‐suppressing or tumor‐promoting roles in carcinogenesis.