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Diverse and pivotal roles of neddylation in metabolism and immunity
Author(s) -
Zou Tao,
Zhang Jiyan
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15584
Subject(s) - neddylation , nedd8 , ubiquitin , cullin , ubiquitin ligase , microbiology and biotechnology , biology , immune system , biochemistry , immunology , gene
Neddylation has been shown to regulate immune responses and metabolism for over a decade. This review presents a comprehensive overview of the roles of neddylation in redox homeostasis, mitochondrial oxidative phosphorylation, de novo lipogenesis, adipogenesis, inflammation, bacterial and viral infection, and adapted immunity. The neddylation substrates involved are discussed.